Growth factor-induced phosphoinositide 3-OH kinase/Akt phosphorylation in smooth muscle cells: induction of cell proliferation and inhibition of cell death.

@article{Jung2000GrowthFP,
  title={Growth factor-induced phosphoinositide 3-OH kinase/Akt phosphorylation in smooth muscle cells: induction of cell proliferation and inhibition of cell death.},
  author={Frank Jung and Judith Haendeler and Christine G{\"o}bel and Andreas Michael Zeiher and Stefanie Dimmeler},
  journal={Cardiovascular research},
  year={2000},
  volume={48 1},
  pages={148-57}
}
OBJECTIVE The signaling pathways mediating proliferation and apoptosis in vascular smooth muscle cells (VSMC) are not well established. It has previously been shown that activation of the phosphoinositide 3-OH kinase (PI3K)/Akt pathway or the ERK 1/2 pathway can mediate anti-apoptotic function in different cell types. This study determined the specific contribution of the PI3K/Akt and ERK pathway in the regulation of apoptosis and proliferation of VSMC. METHODS AND RESULTS Incubation of rat… CONTINUE READING
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