Growth factor-extracellular matrix synergy in the control of trophoblast invasion.

  title={Growth factor-extracellular matrix synergy in the control of trophoblast invasion.},
  author={John D Aplin and Helen Lacey and Teresa Haigh and Carolyn J. P. Jones and Cui Ping Chen and M. Westwood},
  journal={Biochemical Society transactions},
  volume={28 2},
At the periphery of the human placenta, trophoblast attaches to the uterine wall. The tissue interface contains many anchoring sites, with cytotrophoblast columns that form bridges between the overlying extraembryonic (villous) mesenchyme and the maternal decidual stroma beneath. From the periphery of these columns, large numbers of trophoblast cells detach, migrate through the decidua and eventually colonize and transform maternal arteries. In this way the placenta increases and gives priority… CONTINUE READING
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