Growth factor and procollagen type I gene expression in human liver disease.

  title={Growth factor and procollagen type I gene expression in human liver disease.},
  author={Giuseppe Malizia and Elizabeth M. Brunt and Marion G. Peters and Angela Rizzo and Thomas J Broekelmann and John Alan McDonald},
  volume={108 1},
BACKGROUND/AIMS Growth factors have been implicated in the pathogenesis of liver fibrosis, a major determinant of the clinical course of chronic liver disease. The aim of this study was to study the relationship of growth factor expression to inflammation and fibrosis in a variety of human liver diseases. METHODS We studied by in situ hybridization the expression of transforming growth factor (TGF) beta 1, platelet-derived growth factor (PDGF) A and PDGF-B, and procollagen type I (pro-I… CONTINUE READING
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