Growth factor and cytokine gene expression in mechanically strained human osteoblast-like cells: implications for distraction osteogenesis.

@article{Cillo2000GrowthFA,
  title={Growth factor and cytokine gene expression in mechanically strained human osteoblast-like cells: implications for distraction osteogenesis.},
  author={Joseph E Cillo and Robert Ga\ssner and Richard R Koepsel and Michael J. Buckley},
  journal={Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics},
  year={2000},
  volume={90 2},
  pages={147-54}
}
OBJECTIVE An understanding of bone cellular biology is a basic necessity to understanding events such as distraction osteogenesis. The goal of this study was to determine the effect of continuous cyclic mechanical stretch as a fundamental event in distraction osteogenesis on the expression of 3 bone growth factors, transforming growth factor-beta 1 (TGF-beta1), insulin-like growth factor 1 (IGF-1), basic fibroblast growth factor (bFGF) and 2 cytokines, interleukin (IL)-1 (IL-1) and 6 (IL-6) in… CONTINUE READING