Growth differentiation factor 15 stimulates rapamycin-sensitive ovarian cancer cell growth and invasion

@inproceedings{Griner2013GrowthDF,
  title={Growth differentiation factor 15 stimulates rapamycin-sensitive ovarian cancer cell growth and invasion},
  author={Samantha E. Griner and Jayashree P. Joshi and Rita Nahta},
  booktitle={Biochemical pharmacology},
  year={2013}
}
Identification of novel molecular markers and therapeutic targets may improve survival rates for patients with ovarian cancer. In the current study, immunohistochemical (IHC) analysis of two human ovarian tumor tissue arrays showed high staining for GDF15 in a majority of tissues. Exogenous stimulation of ovarian cancer cell lines with recombinant human GDF15 (rhGDF15) or stable over-expression of a GDF15 expression plasmid promoted anchorage-independent growth, increased invasion, and up… CONTINUE READING
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