Growth differentiation factor-15/macrophage inhibitory cytokine-1 induction after kidney and lung injury.

@article{Zimmers2005GrowthDF,
  title={Growth differentiation factor-15/macrophage inhibitory cytokine-1 induction after kidney and lung injury.},
  author={Teresa A. Zimmers and Xiaoling Jin and Edward C Hsiao and Sharon A McGrath and Aurora F Esquela and Leonidas G. Koniaris},
  journal={Shock},
  year={2005},
  volume={23 6},
  pages={543-8}
}
The immunoregulatory cytokine macrophage inhibitory cytokine-1 (MIC-1), a divergent TGF-beta family member, and its murine ortholog, growth/differentiation factor-15 (GDF-15) are induced in hepatocytes by surgical and chemical injury and heat shock. To better understand the in vivo role this factor plays in organ injury, we examined the regulation of GDF-15 in murine models of kidney and lung injury. We demonstrate herein induction of GDF-15/MIC-1 after surgical, toxic/genotoxic, ischemic, and… CONTINUE READING

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