Growth dependence of conjugation explains limited plasmid invasion in biofilms: an individual-based modelling study.

Abstract

Plasmid invasion in biofilms is often surprisingly limited in spite of the close contact of cells in a biofilm. We hypothesized that this poor plasmid spread into deeper biofilm layers is caused by a dependence of conjugation on the growth rate (relative to the maximum growth rate) of the donor. By extending an individual-based model of microbial growth and… (More)
DOI: 10.1111/j.1462-2920.2011.02535.x

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