Growth control or terminal differentiation: endogenous production and differential activities of vitamin A metabolites in HL-60 cells

@article{Eppinger1993GrowthCO,
  title={Growth control or terminal differentiation: endogenous production and differential activities of vitamin A metabolites in HL-60 cells},
  author={T M Eppinger and Jochen Buck and Ulrich H{\"a}mmerling},
  journal={The Journal of Experimental Medicine},
  year={1993},
  volume={178},
  pages={1995 - 2005}
}
Vitamin A (retinol) is a prohormone that exerts its pleiotropic biological effects after conversion into multiple metabolites. In this report we describe the identification of three endogenous, retinolderived effector molecules, 14-hydroxy-retro-retinol (14-HRR), anhydroretinol (AR), and retinoic acid (RA) and a putative storage form of retinol, retinylesters (RE) in the human promyelocytic leukemia cell line HL-60. Exogenous application of the retinol metabolites in retinol-depleted serum-free… CONTINUE READING

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