Growth control of prostatic carcinoma cells in serum-free media: interrelationship of hormone response, cell density, and nutrient media.

@article{Kaighn1981GrowthCO,
  title={Growth control of prostatic carcinoma cells in serum-free media: interrelationship of hormone response, cell density, and nutrient media.},
  author={M. Edward Kaighn and David N. Kirk and M F Szalay and John F. Lechner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1981},
  volume={78 9},
  pages={5673-6}
}
Two established prostatic carcinoma cell lines have been grown in long-term culture in a defined medium (PFMR-4) free of serum, hormones, or growth factors. Growth of both lines in serum-free medium was population dependent. This cell-density requirement could be replaced by mitomycin C-inactivated feeder cells, homologous conditioned medium, or fetal bovine serum, but not by hormones or growth factors. The cells responded to these factors only at high density. The nature of this hormonal… CONTINUE READING
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