Growth control of embryonic stem cells injected into mouse uterus on fifth day of pregnancy.

@article{Monzo1994GrowthCO,
  title={Growth control of embryonic stem cells injected into mouse uterus on fifth day of pregnancy.},
  author={M Monzo and Josep Maria de Anta and B Honrubia Peris and Domingo Gil Ruano},
  journal={International journal of cancer},
  year={1994},
  volume={56 3},
  pages={
          387-92
        }
}
Previous studies have shown that embryonic stem cells (ES) may participate in normal embryonic development when they are injected into the blastocyst. In contrast, ES cells develop into tumors if injected in ectopic sites in adult mice. In this study we injected ES-D3 cells, with the LacZ gene incorporated, into 5-day pregnant mouse uteri, into pregnant unilaterally salpingectomized uteri, into pseudopregnant uteri and into non-pregnant uteri. X-gal staining enabled us to identify injected ES… CONTINUE READING
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