Growth cone steering by receptor tyrosine phosphatase delta defines a distinct class of guidance cue.

@article{Sun2000GrowthCS,
  title={Growth cone steering by receptor tyrosine phosphatase delta defines a distinct class of guidance cue.},
  author={Qi Lun Sun and Joy Y Wang and Richard J. Bookman and John L. Bixby},
  journal={Molecular and cellular neurosciences},
  year={2000},
  volume={16 5},
  pages={686-95}
}
Receptor-type tyrosine phosphatases (RPTPs) are involved in pathfinding decisions by elongating axons, but how they function in these decisions remains unclear. A vertebrate RPTP, PTP-delta, is a neurite-promoting homophilic adhesion molecule; here we demonstrate chemoattraction of CNS growth cones by a locally applied gradient of soluble PTP-delta. The attractive effect of PTP-delta was abolished by inhibition of tyrosine phosphatase activity, but in contrast to other guidance proteins was… CONTINUE READING