Growth cone behavior on gradients of substratum bound laminin.

  title={Growth cone behavior on gradients of substratum bound laminin.},
  author={Malachy McKenna and Jonathan A. Raper},
  journal={Developmental biology},
  volume={130 1},
We have tested the ability of a gentle gradient of neurite-promoting activity to orient the extension of embryonic growth cones. Gradients of neurite-promoting activity were made with biologically active, tritium-labeled laminin. The distributions of laminin bound to glass substrata were visualized by autoradiography and quantified with an image processing system. Embryonic chick sympathetic ganglia were explanted onto laminin gradients and cultured. No tendency for neurites to be oriented up… CONTINUE READING

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