Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5).

@article{MourtadaMaarabouni2008GrowthAI,
  title={Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5).},
  author={Mirna Mourtada-Maarabouni and Vanessa L Hedge and Lucy A Kirkham and Farzin Farzaneh and Gwyn T. Williams},
  journal={Journal of cell science},
  year={2008},
  volume={121 Pt 7},
  pages={939-46}
}
The control of growth of lymphocyte populations is crucial to the physiological regulation of the immune system, and to the prevention of both leukaemic and autoimmune disease. This control is mediated through modulation of the cell cycle and regulation of cell death. During log-phase growth the rate of proliferation is high and there is a low rate of cell death. As the population density increases, the cell cycle is extended and apoptosis becomes more frequent as the population enters growth… CONTINUE READING