Growth arrest and DNA damage-45 alpha (GADD45alpha).

  title={Growth arrest and DNA damage-45 alpha (GADD45alpha).},
  author={A Rosemary Siafakas and Des. R. Richardson},
  journal={The international journal of biochemistry & cell biology},
  volume={41 5},
Regulation of cell cycle and growth is integral for cell survival. The intricate mechanisms that control proliferation and cell cycle are numerous. The growth arrest and DNA damage (GADD)-inducible gene family is often up-regulated in response to various environmental stresses and drug therapies. GADD45alpha was the first stress-inducible gene determined to be up-regulated by p53 and is also a target for the p53 homologues, p63 and p73. When GADD45alpha is deleted or repressed, cells show… CONTINUE READING

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