Growth and intestinal differentiation are independently regulated in HT29 colon cancer cells.

@article{Schroy1994GrowthAI,
  title={Growth and intestinal differentiation are independently regulated in HT29 colon cancer cells.},
  author={Paul C. Schroy and Anil K Rustgi and E Ikonomu and Xiu Ping Liu and Jessica Polito and Chris Andry and J C O'keane},
  journal={Journal of cellular physiology},
  year={1994},
  volume={161 1},
  pages={111-23}
}
The polar-planar compound hexamethylene bisacetamide (HMBA) can inhibit HT29 colon carcinoma cell growth and induce a more benign phenotype, as defined by decreased anchorage-independent clonogenicity, loss of a cell surface malignancy marker, and decreased in vivo tumorigenicity. The principle aim of this study was to determine whether HMBA's effects on HT29 cell growth and biologic behavior correlate with effects on intestinal differentiation. Parallel studies were performed with sodium… CONTINUE READING