Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4.

Abstract

In a gene trap screen we recovered a mouse mutant line in which an insertion generated a null allele of the Brd4 gene. Brd4 belongs to the Fsh/Brd family, a group of structurally related proteins characterized by the association of two bromodomains and one extraterminal domain. Members of this family include Brd2/Ring3/Fsrg1 in mammals, fs(1)h in Drosophila… (More)

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@article{Houzelstein2002GrowthAE, title={Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4.}, author={Denis Houzelstein and Simon L Bullock and Denise E Lynch and Elena F. Grigorieva and Valerie A. Wilson and Rosa S. P. Beddington}, journal={Molecular and cellular biology}, year={2002}, volume={22 11}, pages={3794-802} }