Growth and differentiation of an embryonal carcinoma cell line (C145b).

@article{Papaioannou1979GrowthAD,
  title={Growth and differentiation of an embryonal carcinoma cell line (C145b).},
  author={Virginia E Papaioannou and Edward P. Evans and Richard L. Gardner and Christopher F Graham},
  journal={Journal of embryology and experimental morphology},
  year={1979},
  volume={54},
  pages={277-95}
}
Several cell and tumour lines were isolated from a single-embryo-derived teratocarcinoma and their karyotypes and differentiation in adult hosts recorded. The majority of cells contained normal karyotypes by banding. The cells were injected into blastocysts and although they sometimes colonized the yolk sac, they never colonized the embryo. Thus the possession of a normal karyotype is not a sufficient condition for embryo colonization. The loss of growth capacity was investigated by studying… CONTINUE READING