Growth and density-dependent regulation of NO synthase by the actin cytoskeleton in pulmonary artery endothelial cells.

@article{Kondrikov2006GrowthAD,
  title={Growth and density-dependent regulation of NO synthase by the actin cytoskeleton in pulmonary artery endothelial cells.},
  author={Dmitry Kondrikov and Hye Rim Han and Edward R. Block and Yunchao Su},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2006},
  volume={290 1},
  pages={
          L41-50
        }
}
We previously reported association of eNOS with actin increases eNOS activity. In the present study, regulation of activity of eNOS by actin cytoskeleton during endothelial growth was studied. We found eNOS activity in PAEC increased when cells grew from preconfluence to confluence. eNOS activity was much greater in PAEC in higher density than those in lower density, suggesting increase in eNOS activity during cell growth is caused by increase in cell density. Although eNOS protein contents… 
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TLDR
The above data suggest that PTN through its receptor RPTPβ/ζ is a mediator of the stimulatory effects of eNOS/NO on human endothelial and prostate cancer cell migration.
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References

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TLDR
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