Growth and Differentiation of Cytoplasmic Membranes in the Course of Lipoprotein Granule Synthesis in the Hepatic Cell

@article{Claude1970GrowthAD,
  title={Growth and Differentiation of Cytoplasmic Membranes in the Course of Lipoprotein Granule Synthesis in the Hepatic Cell},
  author={Albert Claude},
  journal={The Journal of Cell Biology},
  year={1970},
  volume={47},
  pages={745 - 766}
}
The synthesis of "very low" density lipoprotein in liver cells is characterized by the fact that the synthesized products, mostly triglycerides, are processed in the form of discrete, size-limited granules or globules, about 400 A in diameter. The present investigation has been made possible in part by the use of a fixative (OsO(4) in bidistilled H(2)O at pH 6.0, in the absence of electrolytes) particularly effective in preserving cytoplasmic membranes and lipids, and giving them high… CONTINUE READING

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