Growth abnormalities in children and adolescents with juvenile idiopathic arthritis

@article{Bechtold2014GrowthAI,
  title={Growth abnormalities in children and adolescents with juvenile idiopathic arthritis},
  author={Susanne M Bechtold and Dominique Simon},
  journal={Rheumatology International},
  year={2014},
  volume={34},
  pages={1483-1488}
}
AbstractIn patients with juvenile idiopathic arthritis (JIA) growth impairment and variance in body composition are well-known long-term complications. In the active phases of the disease, particular patients with systemic and polyarticular JIA reveal growth impairment. Some experience “catch-up” growth following reduction in disease activity and lower glucocorticoid doses. Although new therapeutic options are available, there are still 10–20 % of patients with severe forms of the disease who… Expand
Growth Pattern in Children with Juvenile Idiopathic Arthritis: A Retrospective Study
TLDR
One in three children with JIA has growth retardation, the severity of which is predicted by low age at disease onset and long disease duration, according to a retrospective chart review of all cases of JIA following up at Pediatric Department of King Abdulaziz University Hospital. Expand
AB0960 Growth and sexual maturation in girls with juvenile idiopathic arthritis
TLDR
It is suggested that even six months after the suspension of glucocorticoid treatment, children with more severe forms of JIA and exposure to higher doses of glucOCorticoids are still susceptible to growth impairment and delayed puberty. Expand
Growth and weight gain in children with juvenile idiopathic arthritis: results from the ReACCh-Out cohort
TLDR
Most children in this modern JIA cohort grew and gained weight as children in the general population and about 1 in 10 children who had systemic arthritis, uncontrolled disease and/or prolonged corticosteroid use, had increased risk of growth impairment. Expand
Growth patterns in early juvenile idiopathic arthritis: Results from the Childhood Arthritis Prospective Study (CAPS)
TLDR
Although overall height at 3 years after initial presentation to rheumatology is within the population norm, as a cohort, children with JIA experience a reduction of growth in height over the first 3 years of disease. Expand
Seminars in Arthritis and Rheumatism
  • 2018
Body composition and phase angle as an indicator of nutritional status in children with juvenile idiopathic arthritis
TLDR
The obtained results indicate a higher risk of malnutrition in children and adolescents with JIA compared to healthy peers, predominantly in patients with polyarthritis. Expand
Low Serum IGF-1 in Boys with Recent Onset of Juvenile Idiopathic Arthritis
TLDR
A sex-dependent deficiency in serum IGF-1 is reported in boys with early JIA, which argues for sex-related differences in biological mechanisms involved in the disease pathogenesis. Expand
Height and sexual maturation in girls with juvenile idiopathic arthritis.
TLDR
These findings suggest that even six months after the suspension of glucocorticoid treatment, children with polyarticular/systemic juvenile idiopathic arthritis subtypes are still susceptible to low height and delayed puberty. Expand
Adiposity in Juvenile Psoriatic Arthritis
TLDR
In this registry, almost 1 in 5 patients with JPsA were obese and more than one-third were overweight, significantly more than expected compared to the US pediatric population, and appropriate longterm followup of this JpsA subgroup is warranted. Expand
Adiposity Is Related to Inflammatory Disease Activity in Juvenile Idiopathic Arthritis
TLDR
No differences were found between JIA patients with well-controlled disease and low disability and the healthy population in body mass index (BMI) or body composition, and the association observed between inflammatory activity and adiposity could be responsible for poorer clinical course. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 56 REFERENCES
Growth hormone improves height in patients with juvenile idiopathic arthritis: 4-year data of a controlled study.
TLDR
The data suggest that long-term growth hormone therapy has a beneficial effect in children with severe forms of JIA and further data are needed to confirm the efficacy and safety of growth hormone and its effect on final height. Expand
Early recombinant human growth hormone treatment in glucocorticoid-treated children with juvenile idiopathic arthritis: a 3-year randomized study.
TLDR
Although rhGH started early in the course of JIA preserved normal growth velocity and height, it was well tolerated and carbohydrate metabolism should be monitored closely. Expand
Total pubertal growth in patients with juvenile idiopathic arthritis treated with growth hormone: analysis of a single center.
  • S. Bechtold, A. Beyerlein, +5 authors H. Schmidt
  • Medicine
  • Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
  • 2012
TLDR
Total pubertal growth in JIA patients treated with GH was increased by a factor of 1.5 greater in comparison to controls leading to a significantly better final height. Expand
Growth hormone increases final height in patients with juvenile idiopathic arthritis: data from a randomized controlled study.
TLDR
The data suggest that long-term GH therapy has a beneficial effect on growth and final height in the majority of growth retarded children with severe forms of JIA. Expand
Growth reconstitution in juvenile idiopathic arthritis treated with etanercept.
TLDR
An intensified anti-inflammatory treatment using etanercept has a beneficial effect on growth in children with a so far uncontrolled inflammatory disease, related to the cessation of the inhibitory effect of proinflammatory cytokines on the synthesis of IGF-1 and IGF-BP-3 in the liver. Expand
GH therapy in juvenile chronic arthritis: results of a two-year controlled study on growth and bone.
TLDR
It is suggested that hGH might be useful in the treatment of growth impairment in JCA, and long-term controlled studies are needed to determine the risks and benefits of GH therapy in J CA. Expand
Dynamics of body composition and bone in patients with juvenile idiopathic arthritis treated with growth hormone.
TLDR
During GH treatment, there was a significant increase and normalization of total bone and muscle CSA at final height and fat mass stabilized at the lower limit of healthy children. Expand
Linear growth and final height in patients with systemic juvenile idiopathic arthritis treated with longterm glucocorticoids.
TLDR
The data suggest that chronic inflammation and prednisone therapy may adversely affect growth in patients with JIA, and that final height may be closely dependent both on the severity of growth retardation during the active phase of the disease and on linear growth after remission. Expand
Growth patterns in juvenile rheumatoid arthritis.
TLDR
Delays in linear growth occurs in some children with JRA and children with RF-positive polyarticular and systemic JRA have more significant growth retardation that occasionally can be sustained and extreme. Expand
Effects of long-term etanercept treatment on growth in children with selected categories of juvenile idiopathic arthritis.
TLDR
Etanercept treatment, with or without methotrexate, may contribute to the restoration of normal growth in children with JIA. Expand
...
1
2
3
4
5
...