Growth Regulation, Imprinted Genes, and Chromosome 11p15.5

  title={Growth Regulation, Imprinted Genes, and Chromosome 11p15.5},
  author={Adam P C Smith and Sanaa Choufani and Jos{\'e} Carlos Ferreira and Rosanna A Weksberg},
  journal={Pediatric Research},
Genomic imprinting refers to parent-of-origin–specific gene expression. Human chromosome band 11p15.5 houses a large cluster of genes that are imprinted. Dysregulation of this gene cluster is associated with the overgrowth and tumor predisposition syndrome, Beckwith-Wiedemann syndrome. Several genes in this imprinted cluster encode proteins involved in growth regulation, e.g. the paternally expressed IGF2 and the maternally expressed cell-cycle regulator cyclin dependent kinase inhibitor… CONTINUE READING
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Epigenetic mutations in 11 p 15 in SilverRussell syndrome are restricted to the telomeric imprinting domain

  • T Eggermann, N Schonherr, +5 authors HA Wollmann
  • J Med Genet
  • 2006

Hypomethylation of the H19 gene causes not only Silver-Russell syndrome (SRS) but also isolated asymmetry or an SRS-like phenotype

  • J Bliek, P Terhal, +8 authors M Mannens
  • Am J Hum Genet
  • 2006

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