Growth Inhibitory Effect of Polyunsaturated Fatty Acids (PUFAs) on Colon Cancer Cells via Their Growth Inhibitory Metabolites and Fatty Acid Composition Changes

@article{Zhang2015GrowthIE,
  title={Growth Inhibitory Effect of Polyunsaturated Fatty Acids (PUFAs) on Colon Cancer Cells via Their Growth Inhibitory Metabolites and Fatty Acid Composition Changes},
  author={Chengcheng Zhang and Haining Yu and Xiaofeng Ni and Shengrong Shen and Undurti N. Das},
  journal={PLoS ONE},
  year={2015},
  volume={10}
}
  • Chengcheng Zhang, Haining Yu, +2 authors Undurti N. Das
  • Published 2015
  • Biology, Medicine
  • PLoS ONE
  • Background Colorectal cancer is common. Polyunsaturated fatty acids (PUFAs) exert growth-inhibitory and pro-apoptotic effects on colon cancer cells. Metabolites of PUFAs such as prostaglandins (PGs), leukotrienes (LTs) and lipoxins (LXs) play a significant role in colon cancer. Methods Human colon cancer LoVo and RKO cells were cultured with different concentration of PUFAs and 5-fluorouracil (5-FU) in vitro. Cell morphological changes, fatty acid composition, formation of PGE2, LTB4 and LXA4… CONTINUE READING

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