Growth Hormone Secretion in Response to Stress in Man

  title={Growth Hormone Secretion in Response to Stress in Man},
  author={F. C. Greenwood and John Landon},
A WIDE variety of emotional and physical stimuli result in increased adrenocortical activity. Thus plasma cortisol-levels rise in response to trauma, surgery, fever and hypoglycaemia1–3. This has been attributed to a stress control mechanism which depends on the integrity of a cerebro-hypothalamo-pituitary-adrenal pathway and overrides the normal ‘negative-feedback’ control mechanism4. An increased secretion of growth hormone has been shown during insulin and tolbutamide induced hypoglycaemia… Expand
Psychologic and Neural Regulation of Growth Hormone Secretion
The mechanisms for growth hormone release and adrenal corticoid activation are independent since dissociation of these two responses is found after a variety of stimuli in man and monkey. Expand
Effect of behavioral stress on plasma levels of growth hormone in sheep
It was concluded from data that behavioral stress does not appear to influence the secretion of growth hormone in sheep. Expand
Adrenergic control mechanism for vasopressin-induced plasma growth hormone response.
It is concluded that the stimulation of growth hormone secretion by vasopressin is mediated at least in part through catecholamine, and inhibited the growth hormone response to approximately one-third of the response in the same subject without adrenergic blockade. Expand
Growth hormone and cortisol responses to psychological stress: comparison of normal and neurotic subjects.
The results indicate that effective psychological coping mechanisms operate in normal man to keep the hormonal response minimum and GH response is a more adequate indicator than cortisol response to psychological stress in neurotics. Expand
Endocrine and neurophysiologic responses of the pituitary to insulin-induced hypoglycemia: a review.
A retrospective analysis of 528 procedures done at an institution between the years 1974 and 1984 is conducted, identifying not only the clinical usefulness of the IH test but also the physiology involved. Expand
A Negative Feedback Mechanism Between Brain Catecholamines and Gamma Amino Butyric Acid, Could Be a Central Defense Mechanism in Stress. A Review Article
The most important hormones involved in stress are catecholamines (CA), adrenocorticotropin (ACTH) and glococorticoids. These hormones guided many biochemical events resulted in hyperglycemia with aExpand
Effect of glucocorticoids on plasma growth hormone in man.
It is possible that the chronicity, the constancy, and the severity of glucocorticoid excess might all be factors in abolishing the plasma GH peaks in Cushing's syndrome. Expand
Neuroendocrine and stress hormone changes during mirthful laughter.
The mirthful laughter experience appears to reduce serum levels of cortisol, dopac, epinephrine, and growth hormone, which have implications for the reversal of the neuroendocrine and classical stress hormone response. Expand
Non-specificity of arginine infusion as a test for growth-hormone secretion.
The results show that rises in plasma-H.G.H. after arginine are no more frequent than those found in the control series due to normal diurnal fluctuations in H.G.'s secretion. Expand
Corticosteroid and growth-hormone response to synthetic lysine-vasopressin, natural vasopressin, saline solution, and venepuncture.
Circulating corticosteroid and growth-hormone values also increased in several volunteers following the intramuscular injection of saline solution when blood-samples were obtained by intermittent venepuncture. Expand


Blood and pituitary ACTH in intact and adrenalectomized rats after stress.
The development of a technic for the analysis of blood ACTH has overcome difficulties and more nearly reflects pituitary activity at any instant and it is entirely possible that stress acting in combination with ACTH will produce an alteration in the concentrations of adrenal metabolites of greater magnitude than that produced by ACTH alone. Expand
Plasma Growth-hormone Levels in Chronic Starvation in Man
BOTH fasting and induced hypoglycaemia are powerful stimuli to secretion of growth hormone in man1–3, but the effect of prolonged starvation on secretion of growth hormone is unknown. It has beenExpand
Cortical and medullary adrenal activity in surgical and allied conditions.
Clinical and experimental investigations have indicated that the pituitary-adrenocortical system is invulnerable to stress, and surgical operations and injuries no doubt represent stress-provoking factors. Expand
Hypoglycemia: A Potent Stimulus to Secretion of Growth Hormone
In normal subjects, hypoglycemia produces an abrupt and sustained rise in levels of human growth hormone in plasma. This effect is independent of insulin, glucagon, or epinephrine. Prolonged fastingExpand
The differential response of the adrenal cortex and medulla to bacterial endotoxin.
  • R. Egdahl
  • Medicine
  • The Journal of clinical investigation
  • 1959
The present studies were set up to determine the effect of bacterial endotoxin on adrenal medullary function, and to use a technique whereby samples of adrenal venous blood could be obtained and analyzed for catechol amines noting the response to various dosages of endotoxin. Expand
Effect of oxytocin, vasopressin, and related peptides on plasma free fatty acids
A significant decrease in the concentration of the free fatty acids of the plasma of nondiabetic or alloxan-diabetic dogs was produced by the intravenous injection of oxytocin, desamino-oxytocin,Expand
Growth Hormone: Important Role in Muscular Exercise in Adults
Measurement by radio-immunoassay of growth hormone in the plasma of adults showed consistently low concentrations in subjects in bed in the morning. Exercise caused marked increases except when theExpand
Studies on the Secretion of Human-pituitary-growth Hormone
Jackson, G. A. (1957). Lancet, 1, 637. James, D. G., and Thomson, A. D. (1955). Quart. 7. Med., 24, 49. Kenney, M., and Stone, D. J. (1963). Amer. Rev. resp. Dis., 87, 504. Lawrence, H. S. (1952). 7.Expand
A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma
A simple fluorimetric method is described for measuring free 11-hydroxycorticoids in human plasma that compares favourably with the methods in current use for estimating urinary steroids, and has the added advantage of not being dependent on the accurate collection of 24-hour urine samples. Expand