Growth Hormone-Releasing Peptides and Their Analogs

  title={Growth Hormone-Releasing Peptides and Their Analogs},
  author={F. Camanni and E. Ghigo and E. Arvat},
  journal={Frontiers in Neuroendocrinology},
  • F. Camanni, E. Ghigo, E. Arvat
  • Published 1998
  • Biology, Medicine
  • Frontiers in Neuroendocrinology
  • Growth hormone-releasing peptides (GHRPs) are a series of hepta (GHRP-1)- and hexapeptides (GHRP-2, GHRP-6, Hexarelin) that have been shown to be effective releasers of GH in animals and humans. More recently, a series of nonpeptidyl GH secretagogues (L-692,429, L-692,585, MK-0677) were discovered using GHRP-6 as a template. Some cyclic peptides as well as penta-, tetra-, and pseudotripeptides have also been described. This review summarizes recent developments in our understanding of the GHRPs… CONTINUE READING
    88 Citations
    Antiproliferative and GH-inhibitory activity of chimeric peptides consisting of GHRP-6 and somatostatin.
    • 12
    Physiology of ghrelin and related peptides.
    • 44
    Pharmacological profile of a new orally active growth hormone secretagogue, SM-130686.
    • 46
    • PDF
    Natural (ghrelin) and synthetic (hexarelin) GH secretagogues stimulate H9c2 cardiomyocyte cell proliferation.
    • 111
    • PDF
    Can GHRH or GH secretagogues re‐initiate pituitary GH pulsatility?
    • 7


    In vitro characterization of four novel classes of growth hormone-releasing peptide.
    • 71
    GH Releasing Peptides - Structure and Kinetics
    • C. Bowers
    • Medicine
    • The Journal of pediatric endocrinology
    • 1993
    • 161