Growth Hormone – Hormone Replacement for the Somatopause?

  title={Growth Hormone – Hormone Replacement for the Somatopause?},
  author={Richard Savine and Peter S{\"o}nksen},
  journal={Hormone Research in Paediatrics},
  pages={37 - 41}
Twenty-four-hour growth hormone (GH) secretion reaches a peak at around puberty and by the age of 21 has begun to decrease. Thereafter the fall in GH secretion is progressive such that by the age of 60 most adults have total 24-hour secretion rates indistinguishable from those of hypopituitary patients with organic lesions in the pituitary gland. Patterns of GH secretion are similar to those in younger people but GH pulses are markedly reduced in amplitude. Sleep and exercise remain the major… 

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This study suggests that organic GH deficiency in the elderly is distinct from the decline in GH secretion associated with the aging process, and patients may benefit from GH replacement therapy.

Growth hormone (GH)-deficient men are more responsive to GH replacement therapy than women.

It is demonstrated that men and women with GHD display marked differences in their responsiveness to GH replacement therapy, and these differences should be taken into consideration when optimizing the treatment of GHD patients.

Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men.

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Programming of growth hormone secretion and bone mineral density in elderly men: a hypothesis.

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The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals.

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Effects of human growth hormone in men over 60 years old.

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Effects of human growth hormone on body composition in elderly men.

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The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency.

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