Growth Hormone – Hormone Replacement for the Somatopause?

@article{Savine2000GrowthH,
  title={Growth Hormone – Hormone Replacement for the Somatopause?},
  author={Richard Savine and Peter S{\"o}nksen},
  journal={Hormone Research in Paediatrics},
  year={2000},
  volume={53},
  pages={37 - 41}
}
Twenty-four-hour growth hormone (GH) secretion reaches a peak at around puberty and by the age of 21 has begun to decrease. Thereafter the fall in GH secretion is progressive such that by the age of 60 most adults have total 24-hour secretion rates indistinguishable from those of hypopituitary patients with organic lesions in the pituitary gland. Patterns of GH secretion are similar to those in younger people but GH pulses are markedly reduced in amplitude. Sleep and exercise remain the major… 

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References

SHOWING 1-10 OF 55 REFERENCES

Beyond the somatopause: growth hormone deficiency in adults over the age of 60 years.

TLDR
This study suggests that organic GH deficiency in the elderly is distinct from the decline in GH secretion associated with the aging process, and patients may benefit from GH replacement therapy.

Growth hormone (GH)-deficient men are more responsive to GH replacement therapy than women.

TLDR
It is demonstrated that men and women with GHD display marked differences in their responsiveness to GH replacement therapy, and these differences should be taken into consideration when optimizing the treatment of GHD patients.

Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men.

TLDR
Short term sc administration of GHRH to healthy old men reverses age-related decreases in GH and IGF-I, suggesting that prolonged treatment could improve age- related alterations in body composition.

Programming of growth hormone secretion and bone mineral density in elderly men: a hypothesis.

TLDR
High peak GH values drive IGF-I production and maintain bone mineralization in adult life, however, integrated GH secretion, after adjusting for the effect of pulse amplitude, is negatively associated with bone density inAdult life.

The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals.

TLDR
Age and pubertal status must be carefully considered when interpreting the IC-GH for patients suspected of having deficient or excessive secretion of GH, as changes in spontaneously secreted growth hormone with aging are examined.

Effects of human growth hormone in men over 60 years old.

TLDR
Diminished secretion of growth hormone is responsible in part for the decrease of lean body mass, the expansion of adipose-tissue mass, and the thinning of the skin that occur in old age.

Effects of human growth hormone on body composition in elderly men.

TLDR
It is postulated that geriatric hyposomatotropism is a contributory cause to the body composition changes described above and tested this hypothesis by recruiting 45 independent men over 61 years old with plasma somatomedin C level below 0.35 U/ml, indicating little or no detectable growth hormone secretion.

The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency.

TLDR
It is concluded that growth hormone has a role in the regulation of body composition in adults, probably through its anabolic and lipolytic actions.
...