Growth Factors and Taurine Protect against Excitotoxicity by Stabilizing Calcium Homeostasis and Energy Metabolism

  title={Growth Factors and Taurine Protect against Excitotoxicity by Stabilizing Calcium Homeostasis and Energy Metabolism},
  author={A. El Idrissi and E. Trenkner},
  journal={The Journal of Neuroscience},
  pages={9459 - 9468}
  • A. El Idrissi, E. Trenkner
  • Published 1999
  • Biology, Medicine
  • The Journal of Neuroscience
  • Taurine, brain derived neurotrophic factor (BDNF), and basic fibroblast growth factor (bFGF) are known to control the development of early postnatal cerebellar granule cells. This study attempted to investigate possible mechanisms of this control by determining neuronal survival, calcium homeostasis, and related calcium-mediated functions, as well as the site of action during glutamate-induced excitotoxicity in cultures of cerebellar granule cells. We report that stimulation of glutamate… CONTINUE READING
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