Growth Factors and Taurine Protect against Excitotoxicity by Stabilizing Calcium Homeostasis and Energy Metabolism

@article{ElIdrissi1999GrowthFA,
  title={Growth Factors and Taurine Protect against Excitotoxicity by Stabilizing Calcium Homeostasis and Energy Metabolism},
  author={Abdeslem El Idrissi and Ekkehart Trenkner},
  journal={The Journal of Neuroscience},
  year={1999},
  volume={19},
  pages={9459 - 9468}
}
Taurine, brain derived neurotrophic factor (BDNF), and basic fibroblast growth factor (bFGF) are known to control the development of early postnatal cerebellar granule cells. This study attempted to investigate possible mechanisms of this control by determining neuronal survival, calcium homeostasis, and related calcium-mediated functions, as well as the site of action during glutamate-induced excitotoxicity in cultures of cerebellar granule cells. We report that stimulation of glutamate… Expand
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Mechanisms Underlying Taurine Protection Against Glutamate-Induced Neurotoxicity
  • H. Ye, Hai-Bo Shi, S. Yin
  • Chemistry, Medicine
  • Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
  • 2013
TLDR
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It is found in vitro, that taurine regulates neuronal calcium homeostasis and calcium-dependent processes, such as protein kinase C (PKC) activity, and as a consequence of calcium regulation, taurines counteracted glutamate-induced mitochondrial damage and cell death. Expand
Beneficial effect of taurine on hypoxia- and glutamate-induced endoplasmic reticulum stress pathways in primary neuronal culture
TLDR
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