Growth Differentiation Factor-15 and Risk of CKD Progression.

  title={Growth Differentiation Factor-15 and Risk of CKD Progression.},
  author={Viji Nair and Cassianne Robinson-Cohen and Michelle Rei Smith and Keith A Bellovich and Zeenat Yousuf Bhat and Maria Bobadilla and Frank C. Brosius and Ian H de Boer and Laurent Essioux and Ivan Formentini and Crystal Ann Gadegbeku and Debbie S. Gipson and Jennifer Hawkins and Jonathan Himmelfarb and Bryan R Kestenbaum and Matthias Kretzler and Maria Chiara Magnone and Kalyani Perumal and Susan P. Steigerwalt and Wenjun Ju and Nisha Bansal},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={28 7},
Growth differentiation factor-15 (GDF-15) is a member of the TGF-β cytokine superfamily that is widely expressed and may be induced in response to tissue injury. Elevations in GDF-15 may identify a novel pathway involved in loss of kidney function among patients with CKD. Among participants in the Clinical Phenotyping and Resource Biobank (C-PROBE) study and the Seattle Kidney Study (SKS), we tested whether kidney tissue expression of GDF15 mRNA correlates with circulating levels of GDF-15 and… CONTINUE READING

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