Growth Control of Differentiated Fetal Rat Hepatocytes in Primary Monolayer Culture

@article{Leffert1974GrowthCO,
  title={Growth Control of Differentiated Fetal Rat Hepatocytes in Primary Monolayer Culture},
  author={Hyam L Leffert},
  journal={The Journal of Cell Biology},
  year={1974},
  volume={62},
  pages={767 - 779}
}
Dialyzed fetal bovine serum contains two distinct growth-controlling macromolecular fractions: one stimulates and the other inhibits proliferation of primary cultured differentiated fetal rat hepatocytes. Both fractions are precipitated by ammonium sulfate (50% saturation, pH 7.4, 4 degrees C). Serum fraction I (SFI, mol wt >/= 120,000 daltons estimated by gel filtration with Bio-gel P200) appears to contain at least two factors which function, respectively, to initiate DNA synthesis (activity… CONTINUE READING

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