Growth Arrest and DNA-damage-inducible Protein 45β-mediated DNA Demethylation of Voltage-dependent T-type Calcium Channel 3.2 Subunit Enhances Neuropathic Allodynia after Nerve Injury in Rats.

Abstract

BACKGROUND Growth arrest and DNA-damage-inducible protein 45β reactivates methylation-silenced neural plasticity-associated genes through DNA demethylation. However, growth arrest and DNA-damage-inducible protein 45β-dependent demethylation contributes to neuropathic allodynia-associated spinal plasticity remains unclear. METHODS Adult male Sprague-Dawley… (More)
DOI: 10.1097/ALN.0000000000001610

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@article{Lai2017GrowthAA, title={Growth Arrest and DNA-damage-inducible Protein 45β-mediated DNA Demethylation of Voltage-dependent T-type Calcium Channel 3.2 Subunit Enhances Neuropathic Allodynia after Nerve Injury in Rats.}, author={Cheng-Yuan Lai and Ming-Chun Hsieh and Yu-Cheng Ho and An-Sheng Lee and Hsueh-Hsiao Wang and Jen-Kun Cheng and Yat-Pang Chau and Hsien-Yu Peng}, journal={Anesthesiology}, year={2017}, volume={126 6}, pages={1077-1095} }