Growth Arrest and Autophagy Are Required for Salivary Gland Cell Degradation in Drosophila

Abstract

Autophagy is a catabolic process that is negatively regulated by growth and has been implicated in cell death. We find that autophagy is induced following growth arrest and precedes developmental autophagic cell death of Drosophila salivary glands. Maintaining growth by expression of either activated Ras or positive regulators of the class I… (More)
DOI: 10.1016/j.cell.2007.10.048

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