Growth/differentiation factor-5 induces growth arrest and apoptosis in mouse B lineage cells with modulation by Smad.

@article{Nakahara2003GrowthdifferentiationFI,
  title={Growth/differentiation factor-5 induces growth arrest and apoptosis in mouse B lineage cells with modulation by Smad.},
  author={Takahiro Nakahara and Kazuhiro Tominaga and Takeyoshi Koseki and Matsuo Yamamoto and Kenji Yamato and Jinichi Fukuda and Tatsuji Nishihara},
  journal={Cellular signalling},
  year={2003},
  volume={15 2},
  pages={181-7}
}
Bone morphogenetic proteins, including growth/differentiation factor-5 (GDF-5), are multifunctional cytokines. Recent studies of intracellular signal transduction mechanisms for the transforming growth factor-beta superfamily have focused on Smad proteins. However, scant attention has been given to the mechanism by which GDF-5 exerts its negative growth effect on immunological competent cells. In the present study, we demonstrated that GDF-5 induced cell cycle arrest in the G1 phase before the… CONTINUE READING

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