Growth, virulence, and immunogenicity of Listeria monocytogenes aro mutants.

@article{Stritzker2004GrowthVA,
  title={Growth, virulence, and immunogenicity of Listeria monocytogenes aro mutants.},
  author={Jochen Stritzker and Jozef Janda and Christoph Schoen and Marcus Taupp and S. A. L. Pilgrim and Ivaylo Gentschev and Peter Prof. Dr. Schreier and Gernot Geginat and W. Goebel},
  journal={Infection and immunity},
  year={2004},
  volume={72 10},
  pages={
          5622-9
        }
}
Mutants of Listeria monocytogenes with deletions in genes of the common branch of the biosynthesis pathway leading to aromatic compounds were constructed as possible virulence-attenuated carrier strains for protein antigens or vaccine DNA. aroA, aroB, and in particular aroE mutants showed strongly reduced growth rates in epithelial cells and even in rich culture media. The metabolism of the aro mutants under these conditions was predominantly anaerobic. Aerobic metabolism and a wild-type growth… CONTINUE READING

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