Growth, telomere dynamics and successful and unsuccessful human aging.

@article{Aviv2003GrowthTD,
  title={Growth, telomere dynamics and successful and unsuccessful human aging.},
  author={Abraham Aviv and Daniel V Levy and Marc Mangel},
  journal={Mechanisms of ageing and development},
  year={2003},
  volume={124 7},
  pages={829-37}
}
This paper links mass trajectories with telomere dynamics to construct theoretical models of successful and unsuccessful aging in human beings. It couples parameters of telomere length in somatic cells, as expressed by the terminal restriction fragment (TRF), at birth and the rate of telomere attrition thereafter with nonlinear models of somatic growth to predict the probability of surviving disease free, based on the assumption that telomere length in replicating somatic cells is a surrogate… CONTINUE READING

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