Growth, phenotype, and function of human intestinal mast cells are tightly regulated by transforming growth factor beta1.

@article{Gebhardt2005GrowthPA,
  title={Growth, phenotype, and function of human intestinal mast cells are tightly regulated by transforming growth factor beta1.},
  author={Thomas Gebhardt and Axel Lorentz and F Detmer and Christian Trautwein and Hueseyin Bektas and Michael P. Manns and Stephan C. Bischoff},
  journal={Gut},
  year={2005},
  volume={54 7},
  pages={928-34}
}
BACKGROUND AND AIMS Transforming growth factor beta1 (TGF-beta1) is expressed in the healthy human intestine and controls mucosal immune responses and inflammation by regulating the function of lymphocytes, macrophages, dendritic cells, and eosinophils. Here, we asked whether human intestinal mast cells (MC) might also be subject to immunoregulation by TGF-beta1. METHODS MC were isolated from the intestinal mucosa, purified, and cultured in vitro in the presence of stem cell factor (SCF) with… CONTINUE READING