Growth, fluctuation and switching at microtubule plus ends

  title={Growth, fluctuation and switching at microtubule plus ends},
  author={Jonathon Howard and Anthony A. Hyman},
  journal={Nature Reviews Molecular Cell Biology},
Recent experiments suggest that microtubules do not grow steadily but instead elongate at a rate that varies in time. We argue that this variation might arise from fluctuations in the length of a dynamic GTP–tubulin cap at the microtubule end. We propose that these fluctuations can lead to a switch in the dynamics of a microtubule end between growth and shrinkage, and provide insight into how the sensitivity of this switch can be changed by microtubule polymerases, such as XMAP215, and tensile… CONTINUE READING

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