Growing Dendrites and Axons Differ in Their Reliance on the Secretory Pathway

@article{Ye2007GrowingDA,
  title={Growing Dendrites and Axons Differ in Their Reliance on the Secretory Pathway},
  author={Bing Ye and Y. W. Zhang and Wei Song and Susan H. Younger and Lily Yeh Jan and Yuh Nung Jan},
  journal={Cell},
  year={2007},
  volume={130},
  pages={717-729}
}
  • Bing Ye, Y. W. Zhang, +3 authors Yuh Nung Jan
  • Published 2007
  • Medicine, Biology
  • Cell
  • Little is known about how the distinct architectures of dendrites and axons are established. From a genetic screen, we isolated dendritic arbor reduction (dar) mutants with reduced dendritic arbors but normal axons of Drosophila neurons. We identified dar2, dar3, and dar6 genes as the homologs of Sec23, Sar1, and Rab1 of the secretory pathway. In both Drosophila and rodent neurons, defects in Sar1 expression preferentially affected dendritic growth, revealing evolutionarily conserved difference… CONTINUE READING

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