Growing Dendrites and Axons Differ in Their Reliance on the Secretory Pathway

@article{Ye2007GrowingDA,
  title={Growing Dendrites and Axons Differ in Their Reliance on the Secretory Pathway},
  author={Bing Ye and Ye W Zhang and Wei Song and Susan H. Younger and Lily Yeh Jan and Yuh Nung Jan},
  journal={Cell},
  year={2007},
  volume={130},
  pages={717-729}
}
Little is known about how the distinct architectures of dendrites and axons are established. From a genetic screen, we isolated dendritic arbor reduction (dar) mutants with reduced dendritic arbors but normal axons of Drosophila neurons. We identified dar2, dar3, and dar6 genes as the homologs of Sec23, Sar1, and Rab1 of the secretory pathway. In both Drosophila and rodent neurons, defects in Sar1 expression preferentially affected dendritic growth, revealing evolutionarily conserved difference… CONTINUE READING
Highly Influential
This paper has highly influenced 28 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 160 extracted citations

Membrane Trafficking in Neuronal Development: Ins and Outs of Neural Connectivity.

International review of cell and molecular biology • 2016
View 5 Excerpts
Highly Influenced

Diversifying the secretory routes in neurons

Front. Neurosci. • 2015
View 4 Excerpts
Highly Influenced

Intrinsic and extrinsic mechanisms of dendritic morphogenesis.

Annual review of physiology • 2015
View 4 Excerpts
Highly Influenced

Cell-intrinsic drivers of dendrite morphogenesis.

Development • 2013
View 7 Excerpts
Highly Influenced

Establishment of axon-dendrite polarity in developing neurons.

Annual review of neuroscience • 2009
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Dual modes of endoplasmic reticulum-to-Golgi transport in dendrites revealed by live-cell imaging.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2003
View 7 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…