GrowMatch: An Automated Method for Reconciling In Silico/In Vivo Growth Predictions

@article{Kumar2009GrowMatchAA,
  title={GrowMatch: An Automated Method for Reconciling In Silico/In Vivo Growth Predictions},
  author={Vinay Satish Kumar and Costas D. Maranas},
  journal={PLoS Computational Biology},
  year={2009},
  volume={5},
  pages={R54 - 141}
}
Genome-scale metabolic reconstructions are typically validated by comparing in silico growth predictions across different mutants utilizing different carbon sources with in vivo growth data. This comparison results in two types of model-prediction inconsistencies; either the model predicts growth when no growth is observed in the experiment (GNG inconsistencies) or the model predicts no growth when the experiment reveals growth (NGG inconsistencies). Here we propose an optimization-based… CONTINUE READING
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