Group up-and-down designs for dose-finding

  title={Group up-and-down designs for dose-finding},
  author={Misrak Gezmua and Nancy Flournoyb},
  • Misrak Gezmua, Nancy Flournoyb
  • Published 2006
Let toxicity to treatment be a Bernoulli random variable for which the probability of failure increases with dose. Consider the problem of identifying a dose having pre-specified probability of failure using data from groups of subjects who arrive sequentially for treatment. There is considerable theory available in this setting for fully sequential up-and-down procedures. This paper presents asymptotic and finite theoretical results for Markovian up-and-down procedures when subjects are… CONTINUE READING