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# Group up-and-down designs for dose-finding

@inproceedings{Gezmua2006GroupUD, title={Group up-and-down designs for dose-finding}, author={Misrak Gezmua and Nancy Flournoyb}, year={2006} }

- Published 2006

Let toxicity to treatment be a Bernoulli random variable for which the probability of failure increases with dose. Consider the problem of identifying a dose having pre-specified probability of failure using data from groups of subjects who arrive sequentially for treatment. There is considerable theory available in this setting for fully sequential up-and-down procedures. This paper presents asymptotic and finite theoretical results for Markovian up-and-down procedures when subjects are… CONTINUE READING