Group sequential monitoring based on the weighted log-rank test statistic with the Fleming-Harrington class of weights in cancer vaccine studies.

Abstract

In recent years, immunological science has evolved, and cancer vaccines are now approved and available for treating existing cancers. Because cancer vaccines require time to elicit an immune response, a delayed treatment effect is expected and is actually observed in drug approval studies. Accordingly, we propose the evaluation of survival endpoints by… (More)
DOI: 10.1002/pst.1760

Topics

Cite this paper

@article{Hasegawa2016GroupSM, title={Group sequential monitoring based on the weighted log-rank test statistic with the Fleming-Harrington class of weights in cancer vaccine studies.}, author={Takahiro Hasegawa}, journal={Pharmaceutical statistics}, year={2016}, volume={15 5}, pages={412-9} }