Group sequential clinical trials for longitudinal data with analyses using summary statistics.

@article{Kittelson2005GroupSC,
  title={Group sequential clinical trials for longitudinal data with analyses using summary statistics.},
  author={John M. Kittelson and Katrina J. Sharples and Scott S. Emerson},
  journal={Statistics in medicine},
  year={2005},
  volume={24 16},
  pages={2457-75}
}
Longitudinal endpoints are used in clinical trials, and the analysis of the results is often conducted using within-individual summary statistics. When these trials are monitored, interim analyses that include subjects with incomplete follow-up can give incorrect decisions due to bias by non-linearity in the true time trajectory of the treatment effect. Linear mixed-effects models can be used to remove this bias, but there is a lack of software to support both the design and implementation of… CONTINUE READING