Group of peptides that act synergistically with hydrophobic antibiotics against gram-negative enteric bacteria

@article{Vaara1996GroupOP,
  title={Group of peptides that act synergistically with hydrophobic antibiotics against gram-negative enteric bacteria},
  author={Martti Vaara and M Porro},
  journal={Antimicrobial Agents and Chemotherapy},
  year={1996},
  volume={40},
  pages={1801 - 1805}
}
  • M. Vaara, M. Porro
  • Published 1 August 1996
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
A synthetic peptide, KFFKFFKFFK [corrected], consisting of cationic lysine residues and hydrophobic phenylalanine residues was found to sensitize gram-negative bacteria to hydrophobic and amphipathic antibiotics. At a concentration of 3 micrograms/ml, it decreased the MIC of rifampin for smooth, encapsulated Escherichia coli by a factor of 300. Other susceptible bacterial species included Enterobacter cloacae, Klebsiella pneumoniae, and Salmonella typhimurium, but Pseudomonas aeruginosa was… Expand
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  • Antimicrobial Agents and Chemotherapy
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