Group antibodies in fluorescent treponemal antibody (FTA) test.

  title={Group antibodies in fluorescent treponemal antibody (FTA) test.},
  author={Katalin Kir{\'a}ly and Antal Jobb{\'a}gy and L. Kov{\'a}ts},
  journal={The Journal of investigative dermatology},
  volume={48 1},
FTA occasionally gives non-specific results. This is caused by group antibodies, which could be absorbed with homogenated or ultra-sonicated T. reiteri. This procedure (FTA-ABS) has been shown to be highly specific and sensitive for the sero-diagnosis of syphilis (1, 2). However, group-antibodies could not be absorbed from all sera (3), which may be explained by the heterogeneity of the group antigens present in saprophytic treponemes. To check the validity of this explanation, the absorptive… 
11 Citations
Fluorescent treponemal antibody inhibition test.
  • A. Wilkinson
  • Biology, Medicine
    The British journal of venereal diseases
  • 1967
The fluorescent treponemal antibody (FTA-200) test has been shown to detect at least two types of antibody in syphilitic serum; one of these is thought to be a group antibody which reacts with an antigen shared by Treponema pallidum and other trep onemes and a second antibody, which remains after such an absorption, is Thought to be specific for T. pallidUM.
Serological tests for treponemal infection in leprosy patients. An evaluation of the fluorescent treponemal antibody absorption (FTA--ABS) test.
This study was undertaken on sera from leprosy patients, to compare the results of the TPI and FTA-ABS tests on those sera which had shown BFP and non-specific reactive results to the more conventional tests for treponemal infection.
Hemagglutination tests and related advances in serodiagnosis of syphilis.
  • R. Shore
  • Medicine, Biology
    Archives of dermatology
  • 1974
Preliminary studies indicate that hemagglutination tests for Treponema pallidum antibodies compare favorably with the fluorescent treponemal antibody absorption (FTA-ABS) test for serodiagnosis of
The Treponema pallidum haemagglutination (TPHA) test in biological false positive and leprosy sera
It was concluded that where reagin and TPHA tests are reactive in a person who has no history or clinical signs of syphilis, the serum should be referred for TPI and FTA-ABS testing.
Immunoglobulin specificity for the fluorescent treponemal antibody-absorption test conjugate
A class-specific anti-human immunoglobulin G conjugate is recommended to replace the present fluorescent treponemal antibody-absorption test conjugates to allow further definition and standardization of the fluorescent trePonemals antibody- absorption test.
Antigenic Analysis of Treponema pallidum: Cross‐reactions between Individual Antigens of T. pallidum and T. Reiter
Seven antigens were demonstrated in the Nichols pathogenic strain of Treponema pallidum when tested by crossed immunoelectrophoresis against rabbit antibodies raised by immunization with T. pallidum
Immunoallergologic Aspects of Syphilis
Syphilis is a chronic infectious disease caused by T. pallidum, systemic from the outset. Since virtually any organ or tissue may be affected, syphilis simulates many diseases. Short symptomatic
The biological false positive reaction to serological tests for syphilis
  • M. Garner
  • Medicine, Biology
    Journal of clinical pathology
  • 1970
It is concluded that sera which give reactive results to reagin detection tests for syphilis and come from patients known to have conditions which cause acute or chronic biological false positive reactions should never be dismissed as such.
A retrospective observational comparative study of VDRL vs. TPHA and their role in serodiagnosis of syphilis in a tertiary care centre
The VDRL and TPHA being simple and economical tests can be combined in the assessment of syphilis and ensures that no cases are missed.


An improved FTA test designated as the FTA absorption procedure (FTA-ABS), whose sensitivity and specificity were determined by testing critical categories of selected human serums, using severa.l PTA test procedures and the Treponerna pallidunim immobilization (TPI) test.
Fluorescent treponemal antibody testing.
The preparation of a fluorescein isothiocyanate immune serum conjugate is described, which is characterized by its antihuman-globulin titre, FITC/protein ratio and staining effect and a combination of the TPCF test with the cardiolipin complement-fixation test appears to be simpler, more sensitive and cheaper.
Treponemal Antigens as Related to Identification and Syphilis Serology
  • W. Deacon, E. F. Hunter
  • Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1962
It is suggested that FA methods can play an important part in future taxonomic studies of treponemes and that the FTA test can be modified so as to increase both sensitivity and specificity.