Group- and Genotype-Specific Neutralizing Antibody Responses Against Respiratory Syncytial Virus in Infants and Young Children With Severe Pneumonia

@inproceedings{Sande2013GroupAG,
  title={Group- and Genotype-Specific Neutralizing Antibody Responses Against
Respiratory Syncytial Virus in Infants and Young Children With Severe
Pneumonia},
  author={Charles Jumba Sande and Martin N. Mutunga and Graham F Medley and Patricia A. Cane and D. James Nokes},
  booktitle={The Journal of infectious diseases},
  year={2013}
}
The effect of genetic variation on the neutralizing antibody response to respiratory syncytial virus (RSV) is poorly understood. In this study, acute- and convalescent-phase sera were evaluated against different RSV strains. The proportion of individuals with homologous seroconversion was greater than that among individuals with heterologous seroconversion among those infected with RSV group A (50% vs 12.5%; P = .0005) or RSV group B (40% vs 8%; P = .008). Seroconversion to BA genotype or non… CONTINUE READING
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