Group X phospholipase A2 stimulates the proliferation of colon cancer cells by producing various lipid mediators.

@article{Surrel2009GroupXP,
  title={Group X phospholipase A2 stimulates the proliferation of colon cancer cells by producing various lipid mediators.},
  author={Fanny Surrel and Ikram Jemel and Eric Boilard and James G. Bollinger and Christine Payr{\'e} and Carine M. Mounier and Kati A Talvinen and Veli Jukka O Laine and Timo J. Nevalainen and Michael H Gelb and G{\'e}rard Lambeau},
  journal={Molecular pharmacology},
  year={2009},
  volume={76 4},
  pages={
          778-90
        }
}
Among mammalian secreted phospholipases A2 (sPLA(2)s), the group X enzyme has the most potent hydrolyzing capacity toward phosphatidylcholine, the major phospholipid of cell membrane and lipoproteins. This enzyme has recently been implicated in chronic inflammatory diseases such as atherosclerosis and asthma and may also play a role in colon tumorigenesis. We show here that group X sPLA(2) [mouse (m)GX] is one of the most highly expressed PLA(2) in the mouse colon and that recombinant mouse and… CONTINUE READING

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