Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is developmentally regulated

@article{Ayala2008GroupIM,
  title={Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is developmentally regulated},
  author={Jennifer Edl Ayala and Colleen M Niswender and Qingwei Luo and Jessica L. Banko and Peter Jeffrey Conn},
  journal={Neuropharmacology},
  year={2008},
  volume={54},
  pages={804-814}
}
Group III metabotropic glutamate receptors (mGluRs) reduce synaptic transmission at the Schaffer collateral-CA1 (SC-CA1) synapse in rats by a presynaptic mechanism. Previous studies show that low concentrations of the group III-selective agonist, L-AP4, reduce synaptic transmission in slices from neonatal but not adult rats, whereas high micromolar concentrations reduce transmission in both age groups. L-AP4 activates mGluRs 4 and 8 at much lower concentrations than those required to activate… CONTINUE READING
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