Group II metabotropic glutamate receptors in anxiety circuitry: correspondence of physiological response and subcellular distribution.

@article{Muly2007GroupIM,
  title={Group II metabotropic glutamate receptors in anxiety circuitry: correspondence of physiological response and subcellular distribution.},
  author={E. Chris Muly and I Mania and Jidong Guo and Donald G. Rainnie},
  journal={The Journal of comparative neurology},
  year={2007},
  volume={505 6},
  pages={682-700}
}
Activation of group II metabotropic glutamate receptors (mGluR2/3) in the amygdala plays a critical role in the regulation of fear and anxiety states. Previous studies using nonselective agonists have suggested this action can result from activation of either pre- or postsynaptic mGluR2/3. Here, we have used a combination of whole-cell patch clamp recording with highly selective agonists (LY354740 and LY379268) and immunoelectron microscopy to examine structure-function relationships for mGluR2… CONTINUE READING

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