Group II metabotropic glutamate receptor activation attenuates traumatic neuronal injury and improves neurological recovery after traumatic brain injury.

@article{Allen1999GroupIM,
  title={Group II metabotropic glutamate receptor activation attenuates traumatic neuronal injury and improves neurological recovery after traumatic brain injury.},
  author={Jeffrey Allen and Svetlana A. Ivanova and Lei Fan and Michael Graham Espey and Anthony S. Basile and Alan I. Faden},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1999},
  volume={290 1},
  pages={112-20}
}
We examined the effects of modulating group II metabotropic glutamate receptors (mGluRs) on traumatic neuronal injury using both in vitro and in vivo models. Treatment with various selective group II mGluR agonists significantly decreased lactate dehydrogenase release, a marker of cell death, after traumatic injury to rat neuronal-glial cultures; injury-induced increases in cyclic AMP and glutamate levels were also significantly reduced by a group II agonist. The neuroprotective effects of… CONTINUE READING

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