Group II and IV phospholipase A(2) are produced in human pancreatic cancer cells and influence prognosis.

@article{Kashiwagi1999GroupIA,
  title={Group II and IV phospholipase A(2) are produced in human pancreatic cancer cells and influence prognosis.},
  author={Masuo Kashiwagi and Helmut Friess and Waldemar Uhl and Pascal O. Berberat and Mohamed Abou-Shady and Marcus Martignoni and Sotirios E. Anghelacopoulos and Arthur Zimmermann and Markus W. B{\"u}chler},
  journal={Gut},
  year={1999},
  volume={45 4},
  pages={605-12}
}
BACKGROUND Phospholipase A(2) (PLA(2)) is involved in regulating biosynthesis of arachidonic acid and its metabolites. There are three major structurally different forms of PLA(2): group I, also called pancreatic PLA(2) (PLA(2)-I); group II, referred to as secretory non-pancreatic or synovial or platelet PLA(2) (PLA(2)-II); group IV, referred to as cytosolic PLA(2) (PLA(2)-IV). AIMS To examine PLA(2)-I, PLA(2)-II, and PLA(2)-IV in normal and pancreatic cancer tissues. Patients-PLA(2) was… CONTINUE READING

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