Group I secreted PLA2 in the maintenance of human lower esophageal sphincter tone.

@article{Cao2000GroupIS,
  title={Group I secreted PLA2 in the maintenance of human lower esophageal sphincter tone.},
  author={Weibiao Cao and Karen M Harnett and Jos{\'e} Behar and Piero Biancani},
  journal={Gastroenterology},
  year={2000},
  volume={119 5},
  pages={1243-52}
}
BACKGROUND & AIMS In cat spontaneous lower esophageal sphincter (LES), tone is maintained by the activity of group I secreted phospholipase A2 (sPLA2-I) that produces arachidonic acid. Arachidonic acid metabolites activate G proteins linked to phospholipases, producing second messengers and activation of a protein kinase C-dependent pathway to maintain tone. We examined the role of sPLA2-I in the maintenance of tone in human LES samples obtained from organ donors. METHODS In vitro LES tone… CONTINUE READING