Group I secreted PLA2 and arachidonic acid metabolites in the maintenance of cat LES tone.

  title={Group I secreted PLA2 and arachidonic acid metabolites in the maintenance of cat LES tone.},
  author={Weibiao Cao and Karen M Harnett and Qian Chen and Mahendra Kumar Jain and Jos{\'e} Behar and Piero Biancani},
  journal={The American journal of physiology},
  volume={277 3 Pt 1},
Spontaneous tone of in vitro lower esophageal sphincter (LES) circular muscle is associated with elevated levels of arachidonic acid (AA), PGF(2alpha), and increased [35S]guanosine 5'-O-(3-thiotriphosphate) (GTPgammaS) binding to Gq-, Gi3-, and G(i1/i2)-like G proteins. Tone and AA levels were reduced by inhibitors of a pancreatic-like (group I) secreted phospholipase A2 (sPLA2), by the cyclooxygenase inhibitor indomethacin, and by the thromboxane A2 antagonist SQ-29548. In addition, pertussis… CONTINUE READING
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PLA2 and arachidonic acid (AA)-induced contraction of lower esophageal sphincter smooth muscle cells (LES) in chronic esophagitis (Abstract)

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Different PKC isozymes mediate lower esophageal sphincter ( LES ) tone and phasic contraction of esophageal ( ESO ) circular smooth muscle in the cat

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Leukotriene-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle (Abstract)

  • N. Kim, I. S. Song, C.W.C.Y. Kim, P. Biancani
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